Search on: MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES 
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Descriptor English:   Mannose-Binding Protein-Associated Serine Proteases 
Descriptor Spanish:   Serina Proteasas Asociadas a la Proteína de Unión a la Manosa 
Descriptor Portuguese:   Serina Proteases Associadas a Proteína de Ligação a Manose 
Synonyms English:   MASP Proteases
MASP-Related Protein
MASPs
MBL-Associated Serine Proteases
MBP-Associated Serine Protease
MBP-Associated Serine Protease-Related Protein
Mannan-Binding Lectin Serine Proteases
Mannose-Binding Protein-Associated Serine Protease
MASP Related Protein
MBL Associated Serine Proteases
MBP Associated Serine Protease
MBP Associated Serine Protease Related Protein
Mannan Binding Lectin Serine Proteases
Mannose Binding Protein Associated Serine Protease
Proteases, MASP
Protein, MASP-Related
Serine Protease, MBP-Associated
Serine Proteases, MBL-Associated  
Tree Number:   D08.811.277.656.300.760.501
D08.811.277.656.959.350.501
D12.776.124.486.274.045.387.875
Definition English:   Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE. 
Indexing Annotation English:   see SCR for organism-specific terms
Pharmacological Action:   Immunologic Factors
 
History Note English:   2006 (1994) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50582 
Unique Identifier:   D050606 

Occurrence in VHL:
 

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